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Basic Research in Modern Biology

Fifty-Two R&D projects having fundamental questions were supported to provide new vistas to the knowledge required for understanding the intricacies involved in applied research.

Research highlights include: promising results for improvement of the oral bio-availability of cyclosporine and reduction of nephrotoxicity associated with the commercial formulation at NIPER, Mohali; Studies carried out at Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, using an in vitro cell culture model to evaluate the response of adult rat cardiac fibroblasts to hypoxia; IISc Bangaluru revealed that UdgB plays a significant role in mycobacteria; Scientists at IMTech., Chandigarh showed that phoP Promoter activity is Autophosphorylation autoregulated by PhoP through sequence-specific interaction(s) involving 3 direct repeat subunits with a 9-bp consensus binding sequence. Studies carried out at IISc, Bangaluru indicated that both MBP and Pre MBP are more prone to aggregation under crowded conditions with pre MBP showing a greater extent of aggregation; Scientists at School of Life Sciences, JNU studied delineation methods to explore the physiological role of SMARCAL 1; Scientist at IISc., Bangalore revealed that the stabilizing contacts in the folded conformations of glycodelins are different; Scientists at CDRI, Lucknow used NMR spectroscopy to solve structure of Mycobacterium tuberculosis, Escherichia coli, and Homo sapiens peptidyl-TRNA hydrolase. A structural model based on E. coli Pth crystal structure, was generated; Crystallographic analysis of PfFbZ of Plasmodium falciparum carried out at IISc., Bangalore revealed new strategies in the design of novel anti-malarials; Studies done at JNU, New Delhi suggested that D. discoideum under oxidative stress exhibits PARP mediated casepase independent paraptotic cell death; Oxidative stress induced DNA damage in ICSI being investigated at IIT Kharagpur revealed a positive correlation between ROS and sperm morphology and its DNA damage; Scientists at ICGEB, New Delhi characterized CIPK protein and showed that the protein contains autophosphorylation activity; Scientists at IIT, Kharagpur attempted to make Folate-Nanoparticle conjugate by grafting folic acid through some bio-compatible non-polymeric coupling agent and Scientists at University of Madras, Chennai are using biophysical techniques, chiefly X-ray crystallography, but also computer modelling, UV spectroscopy and gel mobility, to study the structures of DNA junctions, such as three way and four-way junctions, as well as unusual DNA packing modes that lead to novel microstructures.

Source: National Portal Content Management Team, Reviewed on: 09-02-2011